Mount your NAS as a network drive
Make sure your NAS shows up as a network drive in Finder (over SMB or AFP). Once you see it in Finder, DupliFind can treat it like a regular folder.
You install nothing on the NAS itself. The scan runs on your Mac, the NAS only serves the files.
Scan several drives at once
Add your NAS, your external drive and a local folder in one go. DupliFind groups duplicates across all of those locations, so you instantly see which copy sits where.
Mind the scan time on big drives
A full NAS can hold a lot of files. Set a minimum file size, say 1 MB, so you do not waste time on tiny files.
Reading over the network is slower than a local drive. Start with a single folder to get a feel for it.
Clean up safely over the network
Here too one copy is kept in every group and deleted files move to a quarantine folder first. You can always go back.